Highly accomplished PhD candidate at Huazhong University of Science and Technology, specializing in epigenetics and neurodegeneration with a focus on Alzheimer's disease and PTSD. Leverages expertise in next-generation and single-cell sequencing, alongside robust R/Python bioinformatics, to uncover critical regulatory mechanisms of non-coding RNA and histone modifications. A prolific researcher with 12 co-first authored publications in prestigious journals like Nature Neuroscience and Science Advances, poised to drive innovation in biomedical research.
Wuhan, Hubei, China
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Summary
Leading cutting-edge research in epigenetics and neurodegeneration, focusing on mechanisms of Alzheimer's disease and PTSD through advanced sequencing and bioinformatics analyses.
Highlights
Pioneered research exploring the epigenetic mechanisms in Alzheimer's disease and Post-Traumatic Stress Disorder (PTSD), specifically investigating the regulatory roles of non-coding RNA and histone modifications on nervous system function and pathology.
Mastered Next-Generation Sequencing (NGS) and single-cell sequencing technologies, performing robust R/Python-based bioinformatics analyses to derive critical insights from complex genomic data.
Authored 12 high-impact publications as a co-first author, including prominent works in Nature Neuroscience (IF: 20.0) and Science Advances (IF: 12.5), significantly advancing the understanding of neurodegeneration.
Actively participated in multiple National Natural Science Foundation of China (NSFC) key and general projects, contributing to significant national research initiatives.
Developed and executed comprehensive molecular, cellular, and animal experimental protocols, demonstrating strong practical research capabilities and ensuring rigorous scientific outcomes.
Awarded By
Huazhong University of Science and Technology
Awarded for outstanding academic achievement and research contributions.
Awarded By
Huazhong University of Science and Technology
Recognized for exemplary performance in academics, morality, and physical fitness.
Awarded By
Huazhong University of Science and Technology
Awarded for commendable academic performance and active participation in university life.
Awarded By
Huazhong University of Science and Technology
Recognized for exemplary performance in academics, morality, and physical fitness.
Published by
Nature Neuroscience
Summary
Co-first author; Impact Factor: 20.0. Investigated the role of spinal cord Tau pathology in tactile deficits and cognitive impairment in Alzheimer's disease via CCK neuron dysregulation.
Published by
Molecular Neurodegeneration
Summary
Co-first author; Impact Factor: 17.5. Explored the connection between brain somatic mutations and neurodegeneration in Alzheimer's disease, highlighting genetic mosaicism.
Published by
Science Advances
Summary
Co-first author; Impact Factor: 12.5. Demonstrated how Cpeb1 remodels cell type-specific translational programs to facilitate fear extinction mechanisms.
Published by
Molecular Psychiatry
Summary
Co-first author; Impact Factor: 10.1. Re-evaluated the significant contributions of reactive astrocytes to the progression of neurodegeneration.
Neuroscience, Neurodegeneration, Alzheimer's Disease, Post-Traumatic Stress Disorder (PTSD), Epigenetics, Non-coding RNA, Histone Modification, Molecular Biology, Cell Biology, Animal Models.
Next-Generation Sequencing (NGS), Single-Cell Sequencing, Bioinformatics Analysis, R, Python, Bash, Data Analysis.
Scientific Writing, Peer Review (Advanced Science), Academic Committee Membership (CGM North America), Grant Writing Support, Project Management.